Anti-/Propsychotic Drug Signaling via Heteromeric GPCRs—A Balancing Act? | Zendy

Mari Kondo | Zendy; Akira Sawa | Zendy

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Anti-/Propsychotic Drug Signaling via Heteromeric GPCRs—A Balancing Act?

Author(s) -

Mari Kondo,

Akira Sawa

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.11.012

Subject(s) - psychosis , schizophrenia (object oriented programming) , biology , glutamate receptor , metabotropic receptor , neuroscience , g protein coupled receptor , population , receptor , psychiatry , psychology , medicine , biochemistry , environmental health

In this issue, Fribourg et al. provide insight into a molecular basis of psychosis. They reveal that a heteromeric complex formed by the G protein-coupled receptors (GPCRs) for glutamate and serotonin is a convergent site for the activity of anti- or propsychotic drugs, opening a possibility for new therapeutic strategies for schizophrenia.

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