Open AccessKinesins Lead Aging Microtubules to Catastrophe
Author(s) -
Anna Akhmanova,
Marileen Dogterom
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.11.011
Subject(s) - microtubule , tubulin , biology , kinesin , microbiology and biotechnology , biophysics , astral microtubules , cell division , cell , genetics , spindle apparatus
The ability of growing microtubules to undergo catastrophes--abrupt switches from growth to shortening--is one of the key aspects of microtubule dynamics important for shaping cellular microtubule arrays. Gardner et al. show that catastrophes occur at a microtubule age-dependent rate and that depolymerizing kinesins can affect this process in fundamentally different ways.
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