PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic | Zendy

Lesley A. Kane | Zendy; Richard J. Youle | Zendy

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PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

Author(s) -

Lesley A. Kane,

Richard J. Youle

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.10.028

Subject(s) - biology , pink1 , parkin , flag (linear algebra) , mitochondrial dna , mitochondrion , genetics , microbiology and biotechnology , gene , mitophagy , autophagy , medicine , parkinson's disease , apoptosis , disease , mathematics , pure mathematics , algebra over a field

The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.

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