Open AccessDerepressing Nuclear Receptors for Metabolic Adaptation
Author(s) -
Alan R. Saltiel
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.10.027
Subject(s) - biology , adaptation (eye) , nuclear receptor , receptor , microbiology and biotechnology , genetics , neuroscience , gene , transcription factor
NCoR is a corepressor of several transcription factors, including the PPAR family of nuclear receptors in fat and muscle. By specifically deleting NCoR in these tissues, Li et al. and Yamamoto et al. now uncover an important role for NCoR in regulating lipid homeostasis through the coordinated control of different nuclear receptors.
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