Feedback on Fat: p62-mTORC1-Autophagy Connections | Zendy

Jorge Moscat | Zendy; Marı́a T. Diaz-Meco | Zendy

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Feedback on Fat: p62-mTORC1-Autophagy Connections

Author(s) -

Jorge Moscat,

Marı́a T. Diaz-Meco

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.10.021

Subject(s) - mtorc1 , autophagy , biology , adipogenesis , microbiology and biotechnology , signal transducing adaptor protein , signal transduction , energy homeostasis , mechanistic target of rapamycin , pi3k/akt/mtor pathway , apoptosis , biochemistry , receptor , mesenchymal stem cell

Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.

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