Open AccessDueling Ca2+ Sensors in Neurotransmitter Release
Author(s) -
Mingshan Xue,
Νικόλαος Γιαγτζόγλου,
Hugo J. Bellen
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.10.007
Subject(s) - biology , neurotransmitter , neurotransmitter agents , neuroscience , microbiology and biotechnology , central nervous system
Ca(2+)-triggered neurotransmitter release is characterized by two kinetically distinct components: a fast synchronous phase and a slow asynchronous phase. Yao et al. (2011) now report that double C2 domain (Doc2) proteins function as high-affinity Ca(2+) sensors to specifically regulate the asynchronous component of neurotransmitter release.
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