Open AccessWhy Does Morphine Make You Itch?
Author(s) -
Takashi Miyamoto,
Ardem Patapoutian
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.09.026
Subject(s) - morphine , opioid , μ opioid receptor , pharmacology , medicine , receptor , neuroscience , biology
Opioids such as morphine numb pain but often concomitantly induce itch. Liu et al. (2011) now separate the sensation of itch from opioid-induced analgesia, showing that in a subset of spinal neurons, morphine directly induces itch by signaling through a heteromer of opioid- and itch-mediating G protein-coupled receptors.
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