Open AccessHiding in Plain Sight: How HIV Evades Innate Immune Responses
Author(s) -
Nicolas Manel,
Dan R. Littman
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.09.010
Subject(s) - biology , innate immune system , samhd1 , immune system , immunity , gene , human immunodeficiency virus (hiv) , immunology , virology , genetics , reverse transcriptase , rna
Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.
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