Open AccessTranslocation Mapping Exposes the Risky Lifestyle of B Cells
Author(s) -
Rachel Patton McCord,
Job Dekker
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.09.005
Subject(s) - chromosomal translocation , scopus , biology , genetics , physics , combinatorics , microbiology and biotechnology , gene , medline , mathematics , biochemistry
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
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