Molecular Mechanism of Protein Folding in the Cell
Author(s) -
James E. Rothman,
Randy Schekman
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.08.041
Subject(s) - biology , mechanism (biology) , protein folding , folding (dsp implementation) , computational biology , microbiology and biotechnology , genetics , evolutionary biology , engineering , electrical engineering , philosophy , epistemology
F.-Ulrich Hartl and Arthur Horwich will share this year's Lasker Basic Medical Science Award for the discovery of the cell's protein-folding machinery, exemplified by cage-like structures that convert newly synthesized proteins into their biologically active forms. Their fundamental findings reveal mechanisms that operate in normal physiologic processes and help to explain the problems that arise in diseases of protein folding.
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