Open AccessA New Shield for a Cytokine Storm
Author(s) -
Akiko Iwasaki,
Ruslan Medzhitov
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.08.027
Subject(s) - biology , cytokine , cytokine storm , shield , computational biology , immunology , medicine , covid-19 , infectious disease (medical specialty) , paleontology , disease
Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network.
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