Open AccessSIP-ing the Elixir of Youth
Author(s) -
William B. Mair,
Kristan K. Steffen,
Andrew Dillin
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.08.026
Subject(s) - ampk , biology , protein subunit , protein kinase a , kinase , microbiology and biotechnology , genetics , gene
AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.
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