Open AccessA New FOXO Pathway Required for Leukemogenesis
Author(s) -
James R. Downing
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.08.019
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , biology , foxo3 , foxo1 , cancer research , transcription factor , pten , myeloid leukemia , oncogene , microbiology and biotechnology , signal transduction , cell cycle , cancer , genetics , gene
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.
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