Open AccessSignaling through Chromatin: Setting the Scene at Kinetochores
Author(s) -
Michaela Smolle,
Jerry L. Workman
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.08.011
Subject(s) - biology , chromatin , kinetochore , microbiology and biotechnology , genetics , computational biology , evolutionary biology , dna , chromosome , gene
Histone H3 lysine 4 trimethylation needed for transcription is mediated by the Set1 methyltransferase and requires prior monoubiquitination of histone H2B. In this issue, Latham et al. (2011) report that dimethylation of the yeast kinetochore protein Dam1 by Set1 similarly requires H2B monoubiquitination. Thus, H2B ubiquitination signals for methylation beyond chromatin.
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