Open AccessTranscription Factor Loading: Please Take My Place!
Author(s) -
Markus Stratmann,
Ueli Schibler
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.07.037
Subject(s) - biology , transcription factor , genetics , transcription (linguistics) , computational biology , evolutionary biology , gene , linguistics , philosophy
Interactions of transcription factors with chromatin are highly dynamic. Now Voss et al. (2011) demonstrate that two transcription factors with identical DNA-binding specificities do not compete for occupancy at a given DNA element, but instead, one factor can even facilitate the binding of another. This assisted loading probably involves chromatin-remodeling machines.
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