Open AccessRegulatory Revolution: Evolving the “Anti-LacI” Repressor
Author(s) -
Christopher J. Marx
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.07.015
Subject(s) - biology , lac repressor , repressor , genetics , computational biology , gene , transcription factor
Much of adaptation is based upon changes in gene expression, but the emergence of new regulatory logic has not been observed directly. Now, Poelwijk et al. report evolving the lac repressor (LacI) to reverse its regulatory logic, resulting in an "anti-LacI" that represses transcription when bound to its "inducer."
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