A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? | Zendy

Leonardo Salmena | Zendy; Laura Poliseno | Zendy; Yvonne Tay | Zendy; Lev M. Kats | Zendy; Pier Paolo Pandolfi | Zendy

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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Author(s) -

Leonardo Salmena,

Laura Poliseno,

Yvonne Tay,

Lev M. Kats,

Pier Paolo Pandolfi

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.07.014

Subject(s) - biology , competing endogenous rna , rna , computational biology , genetics , evolutionary biology , gene , long non coding rna

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

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