Open AccessA YY1 Bridge for X Inactivation
Author(s) -
Joanne L. Thorvaldsen,
Jamie R. Weaver,
Marisa S. Bartolomei
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.06.029
Subject(s) - biology , yy1 , bridge (graph theory) , genetics , microbiology and biotechnology , gene , anatomy , gene expression , promoter
Xist RNA inactivates one mammalian X chromosome (the Xi) by associating with it in cis. The mechanism of this interaction is unresolved. Jeon and Lee (2011) now show that YY1 binds both Xist RNA and DNA, thereby providing a mechanism to anchor Xist to the Xi and facilitate X chromosome inactivation.
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