p63 and Epithelial Metaplasia: A Gutsy Choice | Zendy

Karine Lefort | Zendy; G. Paolo Dotto | Zendy

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p63 and Epithelial Metaplasia: A Gutsy Choice

Author(s) -

Karine Lefort,

G. Paolo Dotto

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.06.008

Subject(s) - biology , metaplasia , esophagus , intestinal metaplasia , epithelium , population , inflammation , transcription factor , embryonic stem cell , cancer research , microbiology and biotechnology , cancer , pathology , anatomy , immunology , genetics , gene , medicine , demography , sociology

Barrett's esophagus is an epithelial metaplasia associated with an increased risk for cancer, but its underlying mechanisms have been debated. Now Wang et al. (2011) suggest an intriguing explanation for this puzzle: a population of residual embryonic cells, lacking the transcription factor p63, migrates and repopulates a normal tissue damaged by inflammation or gastroesophageal reflux.

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