Open AccessStuck in the Middle: Drugging the Ubiquitin System at the E2 Step
Author(s) -
J. Wade Harper,
Randall W. King
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.06.002
Subject(s) - ubiquitin , biology , deubiquitinating enzyme , ubiquitin conjugating enzyme , allosteric regulation , ubiquitins , ubiquitin protein ligases , microbiology and biotechnology , enzyme , ubiquitin ligase , biochemistry , computational biology , gene
The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway.
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