Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency | Zendy

Stuart M. Chambers | Zendy; Lorenz Studer | Zendy

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Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency

Author(s) -

Stuart M. Chambers,

Lorenz Studer

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.05.036

Subject(s) - biology , reprogramming , microbiology and biotechnology , cell fate determination , genetics , cell , transcription factor , gene

Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.

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