Open AccessRolling ES Cells Down the Waddington Landscape with Oct4 and Sox2
Author(s) -
Nicola Iovino,
Giacomo Cavalli
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.05.027
Subject(s) - sox2 , biology , embryonic stem cell , inner cell mass , stem cell , induced pluripotent stem cell , microbiology and biotechnology , genetics , embryo , gene , embryogenesis , blastocyst
Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al. (2011) now show that two core components of the pluripotency circuit, Oct4 and Sox2, are also critical for germ layer fate choice.
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