Open AccessProtease Power Strokes Force Proteins to Unfold
Author(s) -
Jorge AlegreCebollada,
Pallav Kosuri,
Julio M. Fernández
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.04.007
Subject(s) - biology , protease , computational biology , microbiology and biotechnology , biochemistry , enzyme
ATP-dependent proteases degrade proteins in the cytosol of cells. Two recent articles, by Aubin-Tam et al. (2011) and Maillard et al. (2011 [this issue]), use single-molecule optical tweezers to show directly that these molecular machines use the energy derived from ATP hydrolysis to mechanically unfold and translocate its substrates into the proteolytic chamber.
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