Open AccessAn Antioxidant Link between Sickle Cell Disease and Severe Malaria
Author(s) -
Ashraful Haque,
Christian Engwerda
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.04.004
Subject(s) - malaria , disease , heme , cell , biology , mutation , antioxidant , hemoglobin , plasmodium falciparum , enzyme , gene , immunology , genetics , medicine , biochemistry
Although a link between sickle cell disease and resistance to severe malaria is well established, the biochemical relationship between the two is unknown. Ferreira et al. (2011) show that carriers of the sickle cell mutation increase expression of the heme oxygenase-1 enzyme, which produces antioxidant molecules that may prevent severe disease symptoms.
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