Open AccessDoes Metabolite Deficiency Mark Oncogenic Cell Cycles?
Author(s) -
Ashok R. Venkitaraman
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.04.003
Subject(s) - biology , genome instability , carcinogenesis , cell growth , dna replication , cell cycle , cell division , dna damage , genetics , cancer research , dna synthesis , cell , microbiology and biotechnology , dna , cancer
Genome instability occurs early in the development of most cancers. Bester et al. now provide evidence that oncogenic signals trigger cell division without coordinate nucleotide synthesis, engendering aberrant DNA replication and damage that could promote carcinogenesis. A mismatch between proliferation and metabolite production may characterize oncogenic cell cycles.
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