Open AccessDirectly Observing Therapy: A New View of Drug Tolerance in Tuberculosis
Author(s) -
Jennifer A. Philips,
J. Ernst
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.02.041
Subject(s) - biology , drug , drug tolerance , tuberculosis , mechanism (biology) , efflux , drug resistance , multidrug tolerance , mycobacterium tuberculosis , bacteria , microbiology and biotechnology , immunology , pharmacology , genetics , pathology , medicine , philosophy , epistemology , biofilm
Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.
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