Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers | Zendy

John G. Albeck | Zendy; Joan S. Brugge | Zendy

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Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers

Author(s) -

John G. Albeck,

Joan S. Brugge

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.02.030

Subject(s) - triple negative breast cancer , biology , cancer research , suppressor , breast cancer , protein tyrosine phosphatase , cancer , phosphatase , ptpn11 , oncology , medicine , genetics , phosphorylation , colorectal cancer , kras

"Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.

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