Open AccessInteractome Networks and Human Disease
Author(s) -
Marc Vidal,
Michael E. Cusick,
AlbertLászló Barabási
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.02.016
Subject(s) - interactome , biology , systems biology , biological network , computational biology , modelling biological systems , gene regulatory network , phenotype , genetics , gene , gene expression
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
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