Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes | Zendy

Ben E. Black | Zendy; Don W. Cleveland | Zendy

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Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

Author(s) -

Ben E. Black,

Don W. Cleveland

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.02.002

Subject(s) - biology , centromere , nucleosome , chromatin , histone , genetics , multicellular organism , epigenetics , histone methylation , histone code , chromosome , histone h3 , microbiology and biotechnology , dna methylation , dna , gene , gene expression

Centromeres direct chromosome inheritance, but in multicellular organisms their positions on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The major candidate for the epigenetic mark is chromatin assembled with the histone H3 variant CENP-A. Recent studies offer conflicting evidence for the structure of CENP-A-containing chromatin, including the histone composition and handedness of the DNA wrapped around the histones. We present a model for the assembly and deposition of centromeric nucleosomes that couples these processes to the cell cycle. This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited.

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