Open AccessTargeting Aneuploidy for Cancer Therapy
Author(s) -
Eusebio Manchado,
Marcos Malumbres
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.01.037
Subject(s) - biology , aneuploidy , cancer , cancer research , cancer therapy , cancer cell , genome instability , genetics , dna damage , chromosome , gene , dna
Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?
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