Cancer Genomes Evolve by Pulverizing Single Chromosomes | Zendy

Matthew Meyerson | Zendy; David Pellman | Zendy

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Cancer Genomes Evolve by Pulverizing Single Chromosomes

Author(s) -

Matthew Meyerson,

David Pellman

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.12.025

Subject(s) - chromothripsis , biology , chromosome instability , genome instability , chromosomal rearrangement , genetics , genome , chromosome , cancer , carcinogenesis , chromoplexy , evolutionary biology , gene , karyotype , dna , dna damage , prostate , pca3

A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.

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