Open AccessMitochondrial Stress Signals Revise an Old Aging Theory
Author(s) -
Dong Kyun Woo,
Gerald S. Shadel
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.12.023
Subject(s) - biology , mitochondrion , microbiology and biotechnology , life span , caenorhabditis elegans , signal transduction , neuroscience , evolutionary biology , genetics , gene
In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.
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