Open AccessWnt Signaling: Multivesicular Bodies Hold GSK3 Captive
Author(s) -
Christof Niehrs,
Sergio P. Acebrón
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.12.003
Subject(s) - wnt signaling pathway , gsk 3 , biology , signal transduction , lrp5 , lrp6 , microbiology and biotechnology , phosphorylation , beta catenin , endocytosis , cell , biochemistry
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom