Epigenetics in Alternative Pre-mRNA Splicing | Zendy

Reini F. Luco | Zendy; Mariano Alló | Zendy; Ignacio E. Schor | Zendy; Alberto R. Kornblihtt | Zendy; Tom Misteli | Zendy

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Epigenetics in Alternative Pre-mRNA Splicing

Author(s) -

Reini F. Luco,

Mariano Alló,

Ignacio E. Schor,

Alberto R. Kornblihtt,

Tom Misteli

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.11.056

Subject(s) - biology , rna splicing , epigenetics , alternative splicing , chromatin , computational biology , genetics , histone , exonic splicing enhancer , splicing factor , rna , messenger rna , gene

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.

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