Open AccessER Sheets Get Roughed Up
Author(s) -
Charles Barlowe
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.11.011
Subject(s) - endoplasmic reticulum , biology , ribosome , membrane , microbiology and biotechnology , bent molecular geometry , membrane protein , biophysics , biochemistry , gene , rna , materials science , composite material
The molecular machinery that shapes the endoplasmic reticulum's (ER's) membrane into ordered networks of "smooth" tubules and "rough" sheets is poorly defined. Shibata et al. (2010) now report that sheet-inducing proteins, such as Climp-63, are enriched in the "rough" ER by their association with membrane-bound ribosomes, whereas curvature-inducing proteins localize at highly bent edges of membrane sheets.
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