Ephecting Excitatory Synapse Development | Zendy

Matthew B. Dalva | Zendy

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Ephecting Excitatory Synapse Development

Author(s) -

Matthew B. Dalva

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.10.017

Subject(s) - synaptogenesis , biology , excitatory postsynaptic potential , excitatory synapse , guanine nucleotide exchange factor , neuroscience , synapse , synapse formation , mechanism (biology) , rhoa , microbiology and biotechnology , inhibitory postsynaptic potential , gtpase , signal transduction , philosophy , epistemology

Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 limits the numbers of excitatory synapses that neurons receive, thus identifying a new mechanism controlling synaptogenesis.

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