Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues | Zendy

Jacob H. Hanna | Zendy; Krishanu Saha | Zendy; Rudolf Jaenisch | Zendy

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Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

Author(s) -

Jacob H. Hanna,

Krishanu Saha,

Rudolf Jaenisch

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.10.008

Subject(s) - reprogramming , biology , epigenetics , somatic cell , induced pluripotent stem cell , cell potency , microbiology and biotechnology , cellular differentiation , epigenesis , ectopic expression , stem cell , transcription factor , genetics , embryonic stem cell , cell , dna methylation , cell culture , gene expression , gene

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions.

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