Open AccessThe Myc Connection: ES Cells and Cancer
Author(s) -
Michael E. Rothenberg,
Michael F. Clarke,
Maximilian Diehn
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.09.046
Subject(s) - biology , gene , embryonic stem cell , cancer cell , gene expression profiling , computational biology , cancer , gene expression , genetics , cancer research , microbiology and biotechnology
Gene profiling experiments have revealed similarities between cancer and embryonic stem (ES) cells. Kim et al. (2010) dissect the gene expression signature of ES cells into three functional modules and find that the Myc module, including genes targeted by Myc-interacting proteins, accounts for most of the similarity between ES and cancer cells.
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