Open AccessEmerging Role of ISG15 in Antiviral Immunity
Author(s) -
Brian Skaug,
Zhijian J. Chen
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.09.033
Subject(s) - biology , immunity , isg15 , virology , immunology , computational biology , genetics , immune system , gene , ubiquitin
Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.
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