Open AccessHow to Survive Aneuploidy
Author(s) -
Bülent Çetin,
Don W. Cleveland
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.09.030
Subject(s) - aneuploidy , biology , carcinogenesis , mitosis , genetics , chromosome instability , cell division , cell growth , cell , cell cycle , cancer research , cancer , microbiology and biotechnology , chromosome , gene
Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and increase the cell's proliferative capacities.
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