SnapShot: Nuclear Receptors II | Zendy

Neil J. McKenna | Zendy; Bert W. O’Malley | Zendy

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SnapShot: Nuclear Receptors II

Author(s) -

Neil J. McKenna,

Bert W. O’Malley

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.08.041

Subject(s) - biology , snapshot (computer storage) , receptor , nuclear receptor , computational biology , evolutionary biology , genetics , gene , transcription factor , computer science , operating system

Estrogen-related receptors* ERRα/NR3B1; ERRβ/NR3B2; ERRγ/NR3B3 All major systems with specific isoforms showing peaks of expression in metabolic tissues (ERRα and ERRβ) and the CNS (ERRγ) Structurally homologous to estrogen receptors; bind EREs but not activated by estrogens; modulate the expression of enzymes involved in adipogenesis, energy metabolism, and synthesis of lipids, eicosanoids, and steroids Bone, metabolic, deafness ↑ VEGF, PDK4, PLIN1, RB1CC1, BSP, CYP11A1, CYP27A1, HK2, PLSCR2, VLDLR, TFF1 (ERRα); CDKN1A (ERRβ); HK2, PLSCR2, VLDLR, CYP27A1, CDKN1A, CDKN1B, PDK4 (ERRγ)

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