Phosphotyrosine Signaling: Evolving a New Cellular Communication System | Zendy

Wendell A. Lim | Zendy; Tony Pawson | Zendy

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Phosphotyrosine Signaling: Evolving a New Cellular Communication System

Author(s) -

Wendell A. Lim,

Tony Pawson

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.08.023

Subject(s) - biology , sh2 domain , proto oncogene tyrosine protein kinase src , phosphorylation , protein tyrosine phosphatase , signal transduction , microbiology and biotechnology , tyrosine phosphorylation , tyrosine , kinase , receptor tyrosine kinase , cell signaling , homology (biology) , tyrosine kinase , computational biology , genetics , biochemistry , gene

Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

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