Fishing Out a Sensor for Anti-inflammatory Oils | Zendy

Alan R. Saltiel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Fishing Out a Sensor for Anti-inflammatory Oils

Author(s) -

Alan R. Saltiel

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.08.022

Subject(s) - gpr120 , insulin resistance , inflammation , adipose tissue , proinflammatory cytokine , biology , immune system , receptor , innate immune system , medicine , endocrinology , immunology , diabetes mellitus , biochemistry , g protein coupled receptor

The omega-3 fatty acids have anti-inflammatory and antidiabetic effects in humans. Now, Oh et al. (2010) demonstrate that the G protein-coupled receptor GPR120 is a receptor for omega-3 fatty acids on macrophages and fat cells. Activation of GPR120 by omega-3 fatty acids inhibits multiple inflammation cascades in macrophages and reverses insulin resistance in obese mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research