Open AccessViable Rat-Mouse Chimeras: Where Do We Go from Here?
Author(s) -
Davor Solter
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.08.021
Subject(s) - pdx1 , induced pluripotent stem cell , biology , chimera (genetics) , pancreas , microbiology and biotechnology , stem cell , embryonic stem cell , gene , genetics , transcription factor , endocrinology
In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation.
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