Open AccessThe Language of Histone Crosstalk
Author(s) -
JungShin Lee,
Edwin R. Smith,
Ali Shilatifard
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.08.011
Subject(s) - biology , crosstalk , histone , genetics , microbiology and biotechnology , computational biology , gene , physics , optics
It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.
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