Open AccessStem Cells and DNA Damage: Persist or Perish?
Author(s) -
Andrew A. Lane,
David T. Scadden
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.07.030
Subject(s) - biology , dna damage , stem cell , haematopoiesis , microbiology and biotechnology , dna , genetics
Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.
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