Strategies for Genetic Studies of Complex Diseases | Zendy

Kai Wang | Zendy; Maja Bućan | Zendy; Struan F.A. Grant | Zendy; Gerard Schellenberg | Zendy; Hákon Hákonarson | Zendy

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Strategies for Genetic Studies of Complex Diseases

Author(s) -

Kai Wang,

Maja Bućan,

Struan F.A. Grant,

Gerard Schellenberg,

Hákon Hákonarson

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.07.025

Subject(s) - genome wide association study , biology , international hapmap project , linkage disequilibrium , single nucleotide polymorphism , context (archaeology) , genetics , genetic association , computational biology , evolutionary biology , gene , genotype , paleontology

In a recent Essay published in Cell, McClellan and King discussed genetic heterogeneity and the potential role of rare genetic variants in complex human diseases (McClellan and King, 2010). These important issues, in particular the application of high-throughput sequencing techniques to discover disease genes, are highly relevant to genetics researchers. However, the authors allocated a substantial proportion of their efforts to being critical of the utility of genome-wide association studies (GWAS).

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