The Pioneer Round of Translation: Features and Functions | Zendy

Lynne E. Maquat | Zendy; WoanYuh Tarn | Zendy; Olaf Isken | Zendy

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The Pioneer Round of Translation: Features and Functions

Author(s) -

Lynne E. Maquat,

WoanYuh Tarn,

Olaf Isken

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.07.022

Subject(s) - translation (biology) , biology , ribonucleoprotein , messenger rna , microbiology and biotechnology , messenger rnp , protein biosynthesis , heterogeneous nuclear ribonucleoprotein , rna binding protein , p bodies , rna , genetics , gene

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.

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