Giving Alzheimer's the Old One-Two | Zendy

Michael S. Wolfe | Zendy; Dennis J. Selkoe | Zendy

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Giving Alzheimer's the Old One-Two

Author(s) -

Michael S. Wolfe,

Dennis J. Selkoe

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.07.006

Subject(s) - biology , amyloid precursor protein secretase , peptide , amyloid precursor protein , alzheimer's disease , transcription factor , amyloid (mycology) , retinoic acid , disease , microbiology and biotechnology , neuroscience , cancer research , biochemistry , medicine , gene , botany

A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid beta-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor beta, a potential new therapeutic target for AD.

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