Open AccessSRD5A3: A Surprising Role in Glycosylation
Author(s) -
Ashlee R. Stiles,
David W. Russell
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.07.003
Subject(s) - biology , gene , reductase , glycosylation , steroid , genetics , aromatase , enzyme , hormone , biochemistry , cancer , breast cancer
The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.
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